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Teríma kasíh. 

Against diabetes drug approved by the FDA Committee

U.S. Food and Drug Administration (FDA) approved the committee this week canagliflozin drug for the treatment of adults with type 2 diabetes. The Committee Endrocrinologic and metabolic FDA Advisory voted 10-5 to approve the drug.

Canagliflozin, Johnson & Johnson, who gave the proposed trade name of Invokana will, if also approved by the FDA later this year, the first of a new type of drugs against diabetes to be available in the U.S. It is a selective glucose co-transporter 2 inhibitor that blocks the reabsorption of glucose by the kidneys, which increases the excretion of glucose and lowers blood glucose Blood. People with type 2 diabetes who have kidney reabsorb greater than normal amounts of glucose in the body.

“We are pleased with the positive recommendation of the committee and look forward to working with the FDA to bring this important new treatment for patients in the United States to help them manage their type 2 diabetes,” said Dr. Peter Stein, head of development of diabetes and metabolic disease departments in the region of Janssen Research & Development, Johnson & Johnson R & D has developed the drug. “As a result of today represents an important step towards achieving this goal.”

approval comes after the results of a phase 3 clinical trial were presented at conferences diabetes the last year. According to Janssen, the trial, which involved 10,285 patients, was “the largest program of advanced development for an experimental pharmacological treatment of type 2 diabetes” never submitted to the health authorities. The results showed that canagliflozin improved glycemic control and was associated with weight loss and blood pressure. Side effects of the drug include yeast infections and urinary tract infections.

reports webpronews.com

What do you pay Message of Mark Zuckerberg?

Mashable

made an interesting discovery this week when they tried to send a message to Mark Zuckerberg of Facebook. The system gave them the ability to move the message into the main inbox Mark the place of the Other (aka SPAM) box for the low, low price of only $ 100.

I do not think $ 100 is too much to ask to meet one of the best men in the biz internet. He has a lot on his plate and probably did not have time to go through the spam. But here is an opportunity to put a message in front of him. He will read it. He will answer. You will become best friends. All this for $ 100. Neat.

If

only. . . some people will pay money because it’s worth it, right? But, according to e-Marketer, most people have no interest to pay even a dollar to make their message more visible. More than half of respondents to a survey said they use Facebook Messaging AYTM very often or sometimes, but 90% said they would not pay really.

This is your average Facebook user. What is business? This graph shows that 46% of marketers “respond with private messages on Facebook.”

I do not like the way the question is worded. As social media manager, I reply to messages sent private Facebook page, but I do not send marketing messages to people who do not contact me first.

No matter how you interpret this question, the time is only half of these people plan to continue the practice.

When you skim down the “plan to use in the next 12 months” column, you will notice that almost all of the options is split into two .

The only gain is in the “Nothing” online. In other words, at the moment 14% of traders are not using one of these social media tactics. The next year, even retailers are moving away from social media.

I highly doubt that the majority of buyers will abandon Facebook and Twitter altogether, but this chart shows how we became disillusioned with the whole process.

If you knew with certainty that your message will be read, how much would you pay to have it delivered via Facebook and send it to you?

Power and marketingpilgrim.com

Congress urged to impose new mileage-based tax to pay for road repairs

Here’s a riddle: the government is determined to reduce the average fuel consumption and therefore CO2 emissions of new vehicles. It is even provide federal tax incentives for buyers who choose to go “green”, ie hybrid or all-electrics.

It follows that by reducing fuel consumption, means a lower income in federal taxes on gasoline remained the same since 1993. Without new revenue, the Congressional Budget Office estimates that last August the Highway Trust Fund will need at least $ 110 million in funding for road repairs.

Ah, but government officials have already taken care of that.

According to The Detroit News, the Government Accountability Office offers a program based on the mileage of user fees, which would impose a tax on vehicle miles traveled.

The GAO says that commercial user charges imposed trucks in Germany and New Zealand have resulted in higher taxes and reduced road damage and urges Congress to establish a pilot program.

“Without a federal pilot program to assess the best options for loading trucks and commercial electric vehicles for their road use and the costs and benefits of these systems, Congress lacks essential information for determine if the mileage of these vehicles could be a viable solution for a cost effective tool to help address the challenges of the nation’s surface transportation funding, “said the GAO.

In order to cover the lack of funds, the driver of a vehicle with an average fuel consumption would have to pay $ 108 to $ 248 per year in mileage, compared to U.S. $ 96 today someone pays taxes gasoline.

GAO

a Plan B, as in the case where the mileage tax base does not go through:. gasoline tax increase from 18.4 to 31.6 to 46.6 cents per gallon

As the old adage goes, there is no such thing as a free lunch – not even a “green” one …

By Andrew Tsaousis

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Toyota Yaris Aston Martin Vanquish: IAC ready to provide armor for all vehicles

You would not recognize one if it was parked right next to you, and that is the point. International Armoring Corporation has more than 8,000 armored vehicles during the past decade, and instead of screaming for attention with over-the-top armored Dartz Prombron as ridiculous or cars produced by Conquest Vehicles, IAC prefer its vehicles to keep a low profile. The company has all shielded by a bus 45 feet for a Volkswagen Beetle, while maintaining vehicle near original appearance and performance.

IAC takes only through the use of lightweight components shielding, including 3.9 Armormax material, laminated synthetic fiber which weakens the weight of steel by about a third, which means conversion increases from about 100 to 1000 pounds with IAC. To keep sacrificing performance, IAC upgrade the suspension and brakes, but Mark Burton, President and CEO of the CIA, said that customers should expect a reduction of 7-8 per percent acceleration performance and a 10-15 percent fuel economy hit.

With the easy molding composite Armormax, IAC can take on almost any project application. Even so, some cars are easier to work with than others. For example, a newer model Volkswagen Beetle was screened at the lowest level that protects against handguns high power such as the .44 magnum and .357 magnum. “I do not know if we could make this vehicle a high-powered rifle fire protection, but if we were given enough time, we could probably understand,” said Burton.

Although ICC was invited to Toyota Land Cruisers armor, Lexus LX 570S, Mercedes-Benz G550s, Mercedes-Benz S-class, Escalades Cadillac, Chevrolet Suburbans and the company also took exotic. Ferrari and Aston Martin have all been on the operating table IAC at a given time. Although the new Aston Martin Vanquish recently hit the market, the IAC has performed reconstructive surgery on it. Vanquish the owner he had first to a different company, but the car was taken to IAC after the armor of the car has been tested and needed repairs. Burton said they even equipped economic class cars such as the Toyota Yaris.

While

an armored vehicle and Yaris Beetle is a little unusual, there is no doubt that they do the work. “We had more than 300 attacks against our vehicles, which is a good indication that there is a need for the product,” said Burton.

In terms of price, the cost ranges from $ 50,000 to $ 100,000 on the roof of the vehicle. Special requests can run much higher, as a coach $ 1.2 billion shielded 45 feet. The bus was equipped with light armor equipment costing more than $ 300 per square foot, glass designed and installed communications systems.

Approximately 90 percent of clients are ITC countries. For some clients, in some areas, Burton said feeling an armored vehicle is needed is “almost on the point of how we feel to have a car alarm in some of our vehicles.” In response to this trend, IAC is to open two other sites abroad, which can help to make them more accessible armored vehicles in foreign countries.

armored

IAC could not stand, but Burton said that it certainly can not report them. “It’s kind of fun to watch News CNN, BBC and Fox and see a head of state out of one of your cars.”

Toyota Yaris and Aston Martin Vanquish pictures are manufacturers

By Wide Open Throttle motortrend.com >>